Symbol
Name
ID

B2m
beta-2 microglobulin
MGI:88127

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes

Abnormal circulating IgA level

Decreased circulating IgG level

Abnormal circulating IgM level

Decreased specific antibody response to polysaccharide vaccine

B lymphocytopenia

Reduced natural killer cell count

Abnormal lymph node morphology

Lymphadenopathy

Splenomegaly

Hepatosplenomegaly

Lung abscess

Skin rash

Recurrent respiratory infections

Disease(s) Associated with B2M

familial visceral amyloidosis

immunodeficiency 43

Mouse Phenotypes

insulitis

abnormal T cell number

increased T-helper 1 cell number

decreased CD8-positive, alpha-beta T cell number

absent CD8-positive, alpha-beta T cells

increased gamma-delta T cell number

increased gamma-delta intraepithelial T cell number

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology

decreased IgG level

increased IgM level

abnormal cytotoxic T cell physiology

abnormal interleukin level

abnormal tumor necrosis factor level

decreased level of surface class I molecules

increased interleukin-3 secretion

decreased interleukin-4 secretion

increased tumor necrosis factor secretion

decreased susceptibility to autoimmune diabetes

decreased susceptibility to bacterial infection

increased susceptibility to infection induced morbidity/mortality

decreased susceptibility to parasitic infection

Availability

Mouse Genotype

B2m^tm1Jae/B2m^tm1Jae

B2m^tm1Unc/B2m^tm1Unc

B2m^tm1Unc/B2m^tm1Unc
Tg(GFAP-B2m)9Mdos/?

B2m^tm1Unc/B2m^tm1Unc
Tg(GFAP-B2m)#Mdos/?

B2m^tm1Unc/B2m⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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